4:10s will be beyond useless IMHO. Run all the gear calculators you want.
They will predict your cruising speed/rpm with some accuracy. They cannot predict traction, or in this case, lack thereof. There is not a street legal tire made that will come close to gripping in first or second in a 500+hp / 2400lb / IRS / 4:10 geared car. I am running an SPF with Roush 427R, 3:27 gears with Torsen positraction, TKO600, Avons on the street and BFG drag radials at the strip (only because they are cheaper than Avons-they don't grip any better). I can smoke the tires off the car at anything over a 2000 rpm roll in first gear. You will not be able to touch the accelerator in first without instantly hitting the rev limiter. Sounds like fun.
If anybody is telling you otherwise they are giving you BAD information.