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I went through a very similar exercise recently. My 428 started missing and occasionally backfiring and I tried everything. I also have MSD ignition hardware and eventually swapped out everything before determining that it was the coil. In my case it was the epoxy filled high vibration coil, but I suspect heat to be the source of the failure. My coil is bolted to the front of the driver's side head and gets really hot. I ended up remounting the coil with a large insulator that I think will keep it a little cooler.
Never could find a temperature spec. for an MSD coil, but the new mounting dropped the coil temperature by 10-20 degrees.
Hal
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