Here's the way I do it, I've never had an 
oil leak complaint. 
Start with your engine upside down on the engine stand with clean 
oil pan rails and saddle gasket areas as David has suggested. Then I apply "Hondabond" in the corners where the saddle seal and 
oil pan rails meet (4 corners) then install the saddle seals making sure that they fully engage the creavases where the sealer has been applied. Then apply another thin layer after the saddle seal is in place and install the pan rail gaskets. Then I apply another thin coat of sealer on top of the oil pan rail gasket and then install the pan. The sealer is only applied in the area where the saddle gasket meets the pan rail gasket, in effect making both gaskets one. If you use a one piece gasket you still need to apply sealer in the same areas and on both the engine block side and the oil pan side. Torque the oil pan down evenly and allow the sealer to squeeze out and dry, then trim the sealer with a razor blade when dry.