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I searched this same question yesterday as I was bored and needed something car related. From what I cold see it varied from a good 4 barrel being better than dual quads to no difference, to the dual quads having an increase in horsepower. It seemed like the problem that could happen with a dual quad setup resulting in lower power were situations where there was too much airflow and gas for the engine setup. As others have said, it comes down to the quality of the intake manifold, head porting, cam specs and the size of the carbs. You should talk with your engine builder specifically about this.