Maybe talk to a local engine shop, dyno tuning shop, and see what they have to say.
I guess the best would be to dyno tune your engine at both elevations, for the optimal jetting. Maybe percy's adjustable jet kit would make it convenient to make adjustments.
https://www.summitracing.com/search/...-adjust-a-jets
But, I think it really comes into play with full throttle acceleration, racing. I'm guessing unless you have a "race" engine, maybe leave it alone?