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I am sure the experts here can provide advice on how to optimize your setup and whether to bias it for the altitude or SL conditions, but in general I would not worry too much about a 3500 ft elevation change. Many of us routinely drive our cars between SL conditions and the mountains here in AZ (5-7k elevation) without any troubles. In my younger days we used to drive up to the White Mountains (9K plus) with our carb'd vehicles without any problems, and I know my dad used to drive his t-bird up Pikes Peak with no issues.
We all used to survive just fine in the days before fuel injection!
Good luck!
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