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A 445 is a great fit to a Cobra. I know Brent Lykins has built quite a few and I am sure some have gone into Cobras and he would be a great source of advice. With your transmission and final drive ratio you will need to be careful with cam selection. My 482 has 242/248 durations at .050" with a 112 degree lobe separation angle and it does not like steady state below 2200 rpm. It would be less tolerant in the smaller 445.
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