[Jeb]

The EEC-IV mass air system will handle your stroker. You would just need to get a set of 36lb injectors (at a minimum, don't know your projected HP, but 36lb-ers are good for almost 500HP). You get your motor together, final cam choice, final trans choice, final rear gear choice, then call in the info to the meter-man and have him send you one calibrated for your combo. Then, within reason, if you make changes to your setup, the EEC-IV will deal with them as they occur as it is reading actual air fed into the motor through the mass-air meter rather than inferrring it through lookup tables you've created.

You should try to contact PSB who has apparently just started up his 408 stroker using the stock EEC ECU.