I knew this was coming. You have been itching and salivating every time you get around those big blocks
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From my very limited experience in this field of “stroked engines”, I think taking a 351 block all the way to 427 is really pushing it. Just get a 427 with the works.
But what ever you end up getting, be sure it satisfies your needs. So do it, but do it only once. Good luck.
Hector