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There's no doubt that a mouse could go up the side pipes if it could get to them. Some years ago, I bought a motorcycle for parts. When I removed the pipes, way up by the head, I found a bunch of little blue pellets, which had to have been poison mouse bait.
Not to set myself up as the resident mouse expert here, but another interesting tidbit regarding mice is that they're cannibalistic. If you use the "Tin Cat" type traps (tin box with holes and a little door on each end so the mice can go in but not out) and don't dump the mice out every few days, eventually you'll open the trap and find a bunch of mouse skeletons and assorted bits and one fat mouse. Gives a new meaning to "Serving your fellow mouse..."
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