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Put the motor on a chassis dyno and an Air/Fuel Ratio sniffer. Your WOT A/F ratio should be around 12.5:1 - 13:1. At cruise rpm, 2500 rpm, under light throttle the A/F should be in the neighborhood of 13.5:1 - 14:1. My 418 stroker went through all the jetting and dyno results last year and this seemed to be a good point for a balance between performance, economy and emissions. I have an 850 Holley massaged by Jet Performance on a 418 stroker with 75 jets on the secondaries and 73's on the primaries with #31 shooters.