A big problem with cammers, other than the weight issues, and size, is the combustion chamber. The cammer was designed to used specially shaped pistons (look like closed fists) within its true hemi chamber to achieve 12.5:1 compression (and more).
Not street-friendly, not pump gas friendly, not emissions-friendly.
I was kinda hoping that Ford's new Hurricane engine was designed by some engineers who had a little tradition/skunkwork/slyfox in their veins...engineers who may have speced the new Hurricane bore spacing to match (or be very close) to the old FE's spacing, maybe even allow use of the new Hurricane heads (3V?) on an old FE block maybe (with custom intake etc.). I don't know if there are any hotrodders left at Ford anymore though, or any with imagination or initiative.
Another issue with cammers is the cams themselves: They are not ground 'normally', and finding someone who can custom-grind the pattern is very limited today.
Regardless of all the problems and issues though, it's still the most awesome engine Ford ever delivered.
