If you're running pump gas, the #1 consideration is to build the engine as detonation resistant as possible.
How?
Aluminum heads. Low compression. Ceramic coated pistons and chambers. The right cam. Reasonable boost levels, tuning, and constant monitoring!
And, it goes without saying that the components chosen need to be appropriate for the power and rpm you are going to generate. Quality rods, crank, pistons are a must.
My combo can be seen here:
http://www.racesystems.com/cobra
It's a 433" BBF with a custom V7-JT Vortech setup, fuel injected. 7.88:1 compression, 14psi, 91 octane. I'm using CP pistons, billet crower rods, a forged 429 heavy truck crank, 4-bolt billet mains, aluminum blue thunder heads that flow 410/310, solid roller valvetrain.
I should have it running this spring...I'll post dyno data.