[Excaliber]

I often use the RED Permatex High Strength, which says on the bottle it's for "permanent" installation. I've found the removing or retightening the nuts after installation did not affect the Permatex ability to hold the nut in place "that much".

In fact the "red stuff" is SO brutal it's difficult to remove the nut even after it is totally free of the plastic nylock compound. That red stuff IS "permanent", bonding to the threads very tightly. Instructions say: "Heat or special tools required for Disassembly", BELIEVE IT! This is mean stuff!

Will it weaken the bond if you retorque? Sure. Will it still hold the nut from loosening up? I believe it will! I have found no need to re-torque after using it. But having removed some nuts or retorque some is how I found it. The other colors and compounds of various locktite stuff I'm not sure about. So it may depend on what brand and formulation your using.