If you change the heads. And, to get the right compression and/or clearance, probably the pistons too. Though there are combinations that can be put together that would work with the factory EFI pistons. Optimal, no. Work, yes.
Or, you could build an adapter plate to bolt to the 460 EFI manfold, cork all the injector holes, and run that. It's been done. It works fine for a mild engine.
If you're looking for an affordable turn-key crate motor, try any of the vendors on
www.460ford.com or your Ford Motorsports catalog. There are good values to be found with both.