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Stroker crank would be needed as well as some clearancing of the block. It is almost that easy as long as you use the right parts. A good rotating assembly to turn a 351W into a 427 should run about $1,000-1,500 (or more depending on quality of parts you use) and you can use the standard 351W block with all the same basic machining requirements of a 351W rebuild- bore and hone cylinders, line bore crank, etc.....
If you're thrifty like me, you can buy a 393 stroker crank and use the stock rods and the proper dished 302 pistons and you won't even need to clearance the block. The 393's put out plenty of power and don't have the clearancing or rod angle problems of the 427's in the 351W block.
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