Guess first thing would be if your retired or not. The job market varies quite a bit depending on the region. Jacksonville has always been a very low cost area to live in but places like Orlando have more diverse job markets and somewhat higher wage levels.
For peace and quiet there's no beating the panhandle. Southern Florida is the ultimate "Florida" experiance (south of Titusville). Up here in Jax the ocean looks like lake Erie because the deep water is about nine miles off shore. This is also why Jax rarely gets hit by hurricanes, they typically swing up into the Carolinas following the warm currents.
Thankfully, Jax doesn't stink anymore as the paper mills here switched to making recycled paper instead of cooking ground up southern pine trees in acid. (these plants are still around but mainly out in the middle of nowhere)
If your a golfer, Jacksonville is
the place to be. (assuming your wife is like most and wants you out of the house during the day)
Coming from up north, I think you'll be pleasantly suprised how laid back Florida is. You'll be saying "ya'll" and "fixin' to" before you know it.
Be fore-warned, Jamo will be making fun of you...
Oh, almost forgot. Best darn BBQ you ever et...